Field of testing

The general toxicity test is carried out using suitable laboratory animals according to domestic and international regulations (GLP, OECD Guideline, etc) for the toxicity evaluation of various substances such as medicines, cosmetics, health foods, chemicals and pesticides. The following toxicity tests are what we do.

Single dose toxicity test

This test assesses the acute effects in the body through general symptoms, weight changes, and autopsy findings in rats and mice and non-rodents (dogs, primates), and checks the approximate lethal dose. In addition, this test provides the most basic information for other tests, such as repeated dose toxicity testing.

Repeated dose toxicity test

In this test, the test substance is repeatedly administered to rodents (rat, mouse) and non-rodents (dogs, primates) for a certain period of time to evaluate general symptoms, weight changes, hematological and blood biochemical tests, urinalysis, electrocardiogram, autopsy, long-term weighing and histopathological examination. This is to assess toxicity by deriving harmless or non-toxic amounts, target organs and dose-toxicity response relationships.

Tested areas

- Single dose toxicity test : Oral, transdermal, intravenous, subcutaneous, intradermal, intracutaneous and peritoneal

- Repeated dose of peritoneal toxicity test : Oral, transdermal, intravenous, subcutaneous, intradermal, intracutaneous and peritoneal

Field of testing

Histopathology test

Histopathology test is an important step in the microscopic examination of morphological results for systemic organs in the final stages of toxicity test and efficacy test. We provide step-by-step services ranging from autopsy of various toxicity tests, tissue slide production, microscopic examination and peer review.

Clinical pathology test

In this test, we analyze components such as red blood cells, white blood cells and serum enzyme through hematological and blood biochemical analysis of blood, serum and urine taken during the toxicity test. We use hematology equipment, blood biochemistry equipment, electrolyte equipment, and blood coagulation equipment to analyze and perform reliable tests on the effect of test materials.

Peer Review

In order to increase the reliability of the results of microscopic examination, KTR conducts peer review through domestic and overseas toxicologists, in addition to internal pathologists.

Tested areas

Histopathology test

- Microscopic examination of systemic organs

- Microscopic photography

- Autopsy

- Production histopathological slides by stage (fixing, reprofiling, tissue treatment, embedding, segmentation, dyeing)

Histopathologic slides by stage